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Docetaxel displays potent and broad antineoplastic properties
47-51 / 2014 / 1976-0442(pISSN)
343(2):239-48
Aderbasib (100-1000μM
InChi: InChI=1S/C17H23N3O
M3258 Size:Contact [email protected] for quotation Docetaxel displays potent and broadM3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (5i) inhibitor. M3258 exerts high biochemical (IC50=3. 6 nM) and cellular (IC50=3. 4 nM) potency against the LMP7 subunit. M3258 shows strong antitumor efficacy in multiple myeloma xenograft models. M3258 leads to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in
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